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Effects of sildenafil citrate on peripheral fatigue and exercise performance after exhaustive swimming exercise in rats

Authors
Kim, Tae-WoonPark, Sang-SeoKim, Bo-KyunSim, Young-JeShin, Mal-Soon
Issue Date
12월-2019
Publisher
KOREAN SOC EXERCISE REHABILITATION
Keywords
Sildenafil citrate; Peripheral fatigue; Exhaustive swimming exercise; Monocarboxylate transporter; Neuronal nitric oxide synthase
Citation
JOURNAL OF EXERCISE REHABILITATION, v.15, no.6, pp.751 - 756
Indexed
SCOPUS
KCI
Journal Title
JOURNAL OF EXERCISE REHABILITATION
Volume
15
Number
6
Start Page
751
End Page
756
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/61378
DOI
10.12965/jer.1938712.356
ISSN
2288-176X
Abstract
Sildenafil citrate is a potent and selective inhibitor of phosphodiesterase type-5 used to treat erectile dysfunction. We investigated the effects of sildenafil citrate treatment on peripheral fatigue and exercise performance after exhaustive swimming exercise in rats. The rats in the sildenafil citrate-treated groups received sildenafil citrate orally once a day for 14 consecutive days at respective dosage. On the 14 days after starting experiment, each animal was submitted to swimming test with intensity equivalent to overload. The exhaustion was defined as a state in which coordinated movements did not return to the water surface for breathing within 10 sec. Western blot for monocarboxylate transporter (MCT)1, MCT4, and neuronal nitric oxide synthase (nNOS) were performed. Exhaustive swimming exercise decreased time of exhaustion and increased lactate concentration, however, sildenafil citrate enhanced time of exhaustion and decreased lactate concentration. Exhaustive swimming exercise increased MCT1 and MCT4 expressions in the gastrocnemius muscles and sildenafil citrate further enhanced MCT1 and MCT4 expressions in the exhaustive swimming exercise rats. Exhaustive swimming exercise decreased nNOS expression in the gastrocnemius muscles and sildenafil citrate enhanced nNOS expression in the exhaustive swimming exercise rats. The most potent effect appeared in the 20-mg/kg sildenafil citrate. Sildenafil citrate might be proposed as a potential ergogenic aid through antiperipheral fatigue.
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