A hydroxyethyl derivative of chrysin exhibits anti-inflammatory activity in dendritic cells and protective effects against dextran sodium salt-induced colitis in mice
- Authors
- Song, Ha-Yeon; Kim, Woo Sik; Kim, Jin-Man; Bak, Dong-Ho; Han, Jeong Moo; Lim, Seung-Taik; Byun, Eui-Baek
- Issue Date
- Dec-2019
- Publisher
- ELSEVIER
- Keywords
- Flavonoids; Chrysin derivative; Anti-inflammation; Dendritic cells; Inflammatory bowel disease; DSS-induced colitis
- Citation
- INTERNATIONAL IMMUNOPHARMACOLOGY, v.77
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL IMMUNOPHARMACOLOGY
- Volume
- 77
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/61413
- DOI
- 10.1016/j.intimp.2019.105958
- ISSN
- 1567-5769
- Abstract
- Inflammatory bowel disease (IBD) is a chronic disease that occurs in the intestinal tract. Phyto-ingredients have been evaluated for their ability to protect against IBD because of their anti-inflammatory activities. In our previous study, we identified a novel derivative of chrysin (HE-chrysin) using irradiation technology, which exhibited stronger anti-cancer activity in human colorectal cancer cells than the original chrysin. Here, to determine whether HE-chrysin is a new therapeutic candidate for IBD, we investigated the anti-inflammatory effects of HE-chrysin on bone marrow-derived dendritic cells (BMDCs) and dextran sodium salt (DSS)-induced colitis in mice. HE-chrysin more effectively inhibited BMDC maturation compared to chrysin, as demonstrated by the decreased levels of pro-inflammatory cytokines, surface molecules, antigen-presenting ability, and T cell proliferation/activation in lipopolysaccharide-stimulated BMDCs. These anti-inflammatory effects of HE-chrysin were regulated by mitogen-activated protein kinases and nuclear factor-kappa B. Furthermore, oral administration of HE-chrysin attenuated DSS-induced colitis symptoms and clinical signs in the mouse model. The protective effects of HE-chrysin treatment against colitis were mediated by decreasing Th1- and Th17-type cytokine levels. These results indicate that HE-chrysin is attractive candidate for IBD therapy.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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