The efficacy of powdered polydioxanone in terms of collagen production compared with poly-L-lactic acid in a murine model
DC Field | Value | Language |
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dc.contributor.author | Kim, Chang Min | - |
dc.contributor.author | Kim, Bo Young | - |
dc.contributor.author | Suh, Dong Hye | - |
dc.contributor.author | Lee, Sang Jun | - |
dc.contributor.author | Moon, Hye Rim | - |
dc.contributor.author | Ryu, Hwa Jung | - |
dc.date.accessioned | 2021-08-31T22:48:09Z | - |
dc.date.available | 2021-08-31T22:48:09Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1473-2130 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/61430 | - |
dc.description.abstract | Background: There are many collagen-stimulating fillers, including calcium hydroxyapatite, polycaprolactone (PCL), and poly-L-lactic acid (PLLA), and other materials have been tested. Polydioxanone (PDO) has recently been used as absorbable thread-lifting material due to its collagen-forming effects. PDO in powdered form is expected to be a good material for collagen-producing fillers. Objectives: To evaluate the collagen-producing effects of powdered PDO injection compared with PLLA injection in a murine model. Materials and Methods: Powdered PDO mixed with sodium carboxymethyl cellulose, PLLA, and phosphate-buffered saline was injected on dorsal skin of 8-week-old rat. Tissue samples were obtained 1, 2, and 12 weeks after the procedures for histopathologic review and for real-time PCR to quantify collagen and tissue growth factors. Results: Both PLLA and powdered PDO injections induced granulomatous reactions. Collagen type 1, collagen type 3, TGF-beta 1, TGF-beta 2, and TGF-beta 3 showed increases 2 weeks after injection but decreased 12 weeks after injection for both powdered PDO and PLLA. Conclusion: Our results suggested that powdered PDO injection induces collagen formation more effectively than PLLA injection. Therefore, PDO can be a good option for forming collagen. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | FACE | - |
dc.title | The efficacy of powdered polydioxanone in terms of collagen production compared with poly-L-lactic acid in a murine model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryu, Hwa Jung | - |
dc.identifier.doi | 10.1111/jocd.12894 | - |
dc.identifier.scopusid | 2-s2.0-85062321418 | - |
dc.identifier.wosid | 000518545000050 | - |
dc.identifier.bibliographicCitation | JOURNAL OF COSMETIC DERMATOLOGY, v.18, no.6, pp.1893 - 1898 | - |
dc.relation.isPartOf | JOURNAL OF COSMETIC DERMATOLOGY | - |
dc.citation.title | JOURNAL OF COSMETIC DERMATOLOGY | - |
dc.citation.volume | 18 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1893 | - |
dc.citation.endPage | 1898 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | FACE | - |
dc.subject.keywordAuthor | collagen | - |
dc.subject.keywordAuthor | polydioxanone | - |
dc.subject.keywordAuthor | poly-L-lactic acid | - |
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