The efficacy of powdered polydioxanone in terms of collagen production compared with poly-L-lactic acid in a murine model
- Authors
- Kim, Chang Min; Kim, Bo Young; Suh, Dong Hye; Lee, Sang Jun; Moon, Hye Rim; Ryu, Hwa Jung
- Issue Date
- 12월-2019
- Publisher
- WILEY
- Keywords
- collagen; polydioxanone; poly-L-lactic acid
- Citation
- JOURNAL OF COSMETIC DERMATOLOGY, v.18, no.6, pp.1893 - 1898
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF COSMETIC DERMATOLOGY
- Volume
- 18
- Number
- 6
- Start Page
- 1893
- End Page
- 1898
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/61430
- DOI
- 10.1111/jocd.12894
- ISSN
- 1473-2130
- Abstract
- Background: There are many collagen-stimulating fillers, including calcium hydroxyapatite, polycaprolactone (PCL), and poly-L-lactic acid (PLLA), and other materials have been tested. Polydioxanone (PDO) has recently been used as absorbable thread-lifting material due to its collagen-forming effects. PDO in powdered form is expected to be a good material for collagen-producing fillers. Objectives: To evaluate the collagen-producing effects of powdered PDO injection compared with PLLA injection in a murine model. Materials and Methods: Powdered PDO mixed with sodium carboxymethyl cellulose, PLLA, and phosphate-buffered saline was injected on dorsal skin of 8-week-old rat. Tissue samples were obtained 1, 2, and 12 weeks after the procedures for histopathologic review and for real-time PCR to quantify collagen and tissue growth factors. Results: Both PLLA and powdered PDO injections induced granulomatous reactions. Collagen type 1, collagen type 3, TGF-beta 1, TGF-beta 2, and TGF-beta 3 showed increases 2 weeks after injection but decreased 12 weeks after injection for both powdered PDO and PLLA. Conclusion: Our results suggested that powdered PDO injection induces collagen formation more effectively than PLLA injection. Therefore, PDO can be a good option for forming collagen.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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