Curcumin-loaded biodegradable polyurethane scaffolds modified with gelatin using 3D printing technology for cartilage tissue engineering
DC Field | Value | Language |
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dc.contributor.author | Lee, Min Jeong | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Park, Juri | - |
dc.contributor.author | Ahn, Guk Young | - |
dc.contributor.author | Yun, Tae Hoon | - |
dc.contributor.author | Choi, Inseong | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.contributor.author | Choi, Sung-Wook | - |
dc.date.accessioned | 2021-08-31T22:53:18Z | - |
dc.date.available | 2021-08-31T22:53:18Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1042-7147 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/61478 | - |
dc.description.abstract | We described the curcumin-loaded biodegradable polyurethane (PU) scaffolds modified with gelatin based on three-dimensional (3D) printing technology for potential application of cartilage regeneration. The printing solution of poly(epsilon-caprolactone) (PCL) triol (polyol) and hexamethylene diisocyanate (HMDI) in 2,2,2-trifluoroethanol was printed through a nozzle in dimethyl sulfoxide phase with or without gelatin. The weight ratio of HMDI against PCL triol was varied as 3, 5, and 7 in order to evaluate its effect on the mechanical properties and biodegradation rate. A higher ratio of HMDI resulted in higher mechanical properties and a lower biodegradation rate. The use of gelatin increased the mechanical properties, biodegradation rate, and curcumin release due to the surface cross-linking, nanoporous structure, and surface hydrophilicity of the scaffolds. In vitro study revealed that the released curcumin enhanced the proliferation and differentiation of chondrocyte. The 3D-printed biodegradable PU scaffold modified with gelatin should thus be considered as a potential candidate for cartilage regeneration. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Curcumin-loaded biodegradable polyurethane scaffolds modified with gelatin using 3D printing technology for cartilage tissue engineering | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sung Eun | - |
dc.identifier.doi | 10.1002/pat.4740 | - |
dc.identifier.scopusid | 2-s2.0-85070707856 | - |
dc.identifier.wosid | 000480980200001 | - |
dc.identifier.bibliographicCitation | POLYMERS FOR ADVANCED TECHNOLOGIES, v.30, no.12, pp.3083 - 3090 | - |
dc.relation.isPartOf | POLYMERS FOR ADVANCED TECHNOLOGIES | - |
dc.citation.title | POLYMERS FOR ADVANCED TECHNOLOGIES | - |
dc.citation.volume | 30 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3083 | - |
dc.citation.endPage | 3090 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordAuthor | 3D printing | - |
dc.subject.keywordAuthor | biodegradable polyurethane | - |
dc.subject.keywordAuthor | cartilage regeneration | - |
dc.subject.keywordAuthor | curcumin | - |
dc.subject.keywordAuthor | scaffold | - |
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