Curcumin-loaded biodegradable polyurethane scaffolds modified with gelatin using 3D printing technology for cartilage tissue engineering
- Authors
- Lee, Min Jeong; Kim, Sung Eun; Park, Juri; Ahn, Guk Young; Yun, Tae Hoon; Choi, Inseong; Kim, Hak-Jun; Choi, Sung-Wook
- Issue Date
- 12월-2019
- Publisher
- WILEY
- Keywords
- 3D printing; biodegradable polyurethane; cartilage regeneration; curcumin; scaffold
- Citation
- POLYMERS FOR ADVANCED TECHNOLOGIES, v.30, no.12, pp.3083 - 3090
- Indexed
- SCIE
SCOPUS
- Journal Title
- POLYMERS FOR ADVANCED TECHNOLOGIES
- Volume
- 30
- Number
- 12
- Start Page
- 3083
- End Page
- 3090
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/61478
- DOI
- 10.1002/pat.4740
- ISSN
- 1042-7147
- Abstract
- We described the curcumin-loaded biodegradable polyurethane (PU) scaffolds modified with gelatin based on three-dimensional (3D) printing technology for potential application of cartilage regeneration. The printing solution of poly(epsilon-caprolactone) (PCL) triol (polyol) and hexamethylene diisocyanate (HMDI) in 2,2,2-trifluoroethanol was printed through a nozzle in dimethyl sulfoxide phase with or without gelatin. The weight ratio of HMDI against PCL triol was varied as 3, 5, and 7 in order to evaluate its effect on the mechanical properties and biodegradation rate. A higher ratio of HMDI resulted in higher mechanical properties and a lower biodegradation rate. The use of gelatin increased the mechanical properties, biodegradation rate, and curcumin release due to the surface cross-linking, nanoporous structure, and surface hydrophilicity of the scaffolds. In vitro study revealed that the released curcumin enhanced the proliferation and differentiation of chondrocyte. The 3D-printed biodegradable PU scaffold modified with gelatin should thus be considered as a potential candidate for cartilage regeneration.
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