Semen Cuscutae Administration Improves Hepatic Lipid Metabolism and Adiposity in High Fat Diet-Induced Obese Mice
DC Field | Value | Language |
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dc.contributor.author | Moon, Jiyoung | - |
dc.contributor.author | Ha, Min Jin | - |
dc.contributor.author | Shin, Min-Jeong | - |
dc.contributor.author | Kim, Oh Yoen | - |
dc.contributor.author | Yoo, Eun Hye | - |
dc.contributor.author | Song, Juhyun | - |
dc.contributor.author | Chung, Ji Hyung | - |
dc.date.accessioned | 2021-08-31T22:53:43Z | - |
dc.date.available | 2021-08-31T22:53:43Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/61482 | - |
dc.description.abstract | Since arginase has been shown to compete with nitric oxide (NO) synthase, emerging evidence has reported that arginase inhibition improves obesity by increasing NO production. Semen cuscutae (SC), which is a well-known Chinese medicine, has multiple biological functions such as anti-oxidant function and immune regulation. In this study, we investigated whether the SC as a natural arginase inhibitor influences hepatic lipid abnormalities and whole-body adiposity in high-fat diet (HFD)-induced obese mice. The lipid accumulation was significantly reduced by SC treatment in oleic acid -induced hepatic steatosis in vitro. Additionally, SC supplementation substantially lowered HFD-induced increases in arginase activity and weights of liver and visceral fat tissue, while increasing hepatic NO. Furthermore, elevated mRNA expressions of sterol regulatory element-binding transcription factor 1 (SREBP-1c), fatty-acid synthase (FAS), peroxisome proliferator-activated receptor-gamma (PPAR-gamma)1, and PPAR-gamma 2 in HFD-fed mice were significantly attenuated by SC supplementation. Taken together, SC, as a novel natural arginase inhibitor, showed anti -obesity properties by modulating hepatic arginase and NO production and metabolic pathways related to hepatic triglyceride (TG) metabolism. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | ACTIVATED RECEPTOR-GAMMA | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | LIVER-DISEASE | - |
dc.subject | ENDOTHELIAL DYSFUNCTION | - |
dc.subject | VASCULAR DYSFUNCTION | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | ARGINASE-I | - |
dc.subject | INHIBITION | - |
dc.subject | EXPRESSION | - |
dc.title | Semen Cuscutae Administration Improves Hepatic Lipid Metabolism and Adiposity in High Fat Diet-Induced Obese Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Min-Jeong | - |
dc.identifier.doi | 10.3390/nu11123035 | - |
dc.identifier.scopusid | 2-s2.0-85076711849 | - |
dc.identifier.wosid | 000506917800197 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.11, no.12 | - |
dc.relation.isPartOf | NUTRIENTS | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | ACTIVATED RECEPTOR-GAMMA | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | LIVER-DISEASE | - |
dc.subject.keywordPlus | ENDOTHELIAL DYSFUNCTION | - |
dc.subject.keywordPlus | VASCULAR DYSFUNCTION | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ARGINASE-I | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Semen cuscutae (SC) | - |
dc.subject.keywordAuthor | arginase inhibitor | - |
dc.subject.keywordAuthor | nitric oxide (NO) | - |
dc.subject.keywordAuthor | hepatic steatosis | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | peroxisome proliferator-activated receptor (PPAR) | - |
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