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Semen Cuscutae Administration Improves Hepatic Lipid Metabolism and Adiposity in High Fat Diet-Induced Obese Mice

Authors
Moon, JiyoungHa, Min JinShin, Min-JeongKim, Oh YoenYoo, Eun HyeSong, JuhyunChung, Ji Hyung
Issue Date
12월-2019
Publisher
MDPI
Keywords
Semen cuscutae (SC); arginase inhibitor; nitric oxide (NO); hepatic steatosis; obesity; peroxisome proliferator-activated receptor (PPAR)
Citation
NUTRIENTS, v.11, no.12
Indexed
SCIE
SCOPUS
Journal Title
NUTRIENTS
Volume
11
Number
12
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/61482
DOI
10.3390/nu11123035
ISSN
2072-6643
Abstract
Since arginase has been shown to compete with nitric oxide (NO) synthase, emerging evidence has reported that arginase inhibition improves obesity by increasing NO production. Semen cuscutae (SC), which is a well-known Chinese medicine, has multiple biological functions such as anti-oxidant function and immune regulation. In this study, we investigated whether the SC as a natural arginase inhibitor influences hepatic lipid abnormalities and whole-body adiposity in high-fat diet (HFD)-induced obese mice. The lipid accumulation was significantly reduced by SC treatment in oleic acid -induced hepatic steatosis in vitro. Additionally, SC supplementation substantially lowered HFD-induced increases in arginase activity and weights of liver and visceral fat tissue, while increasing hepatic NO. Furthermore, elevated mRNA expressions of sterol regulatory element-binding transcription factor 1 (SREBP-1c), fatty-acid synthase (FAS), peroxisome proliferator-activated receptor-gamma (PPAR-gamma)1, and PPAR-gamma 2 in HFD-fed mice were significantly attenuated by SC supplementation. Taken together, SC, as a novel natural arginase inhibitor, showed anti -obesity properties by modulating hepatic arginase and NO production and metabolic pathways related to hepatic triglyceride (TG) metabolism.
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