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Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis
- Authors
- Kim, Won Young; Won, Miae; Salimi, Abbas; Sharma, Amit; Lim, Jong Hyeon; Kwon, Seung-Hae; Jeon, Joo-Yeong; Lee, Jin Yong; Kim, Jong Seung
- Issue Date
- 14-11월-2019
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.55, no.88, pp.13267 - 13270
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 55
- Number
- 88
- Start Page
- 13267
- End Page
- 13270
- ISSN
- 1359-7345
- Abstract
- Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.
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