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Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production
- Authors
- Jin, Qinghao; Lee, Jin Woo; Kim, Jun Gu; Lee, Dongho; Hong, Jin Tae; Kim, Youngsoo; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- 11월-2019
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.82, no.11, pp.3002 - 3009
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 82
- Number
- 11
- Start Page
- 3002
- End Page
- 3009
- ISSN
- 0163-3864
- Abstract
- Three biogenetically related ent-sauchinone-type lignans (1-3), four 8-O-4'-type neolignans (4-7), a diaryldimethylbutane lignan (8), and a cyclic carbonate (9), along with 12 known compounds, have been isolated from a methanol extract of the aerial parts of Saururus chinensis. The structures of the new compounds (1-9) were determined by analysis of their 1D and 2D NMR spectra, HRESIMS, and ECD data. A putative biosynthetic pathway for the three ents-auchinone-type lignans (1-3) was postulated. Compounds 1, 7, and 10 showed inhibitory effects on LPS-induced NO production in RAW 264.7 cells with IC50 values of 5.6, 8.6, and 9.2 mu M, respectively.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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