Punicalagin, a Pomegranate-Derived Ellagitannin, Suppresses Obesity and Obesity-Induced Inflammatory Responses Via the Nrf2/Keap1 Signaling Pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Bobin | - |
dc.contributor.author | Kim, Chae Young | - |
dc.contributor.author | Hwang, Jisu | - |
dc.contributor.author | Jo, Kyungae | - |
dc.contributor.author | Kim, Singeun | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Choi, Hyeon-Son | - |
dc.date.accessioned | 2021-09-01T01:16:24Z | - |
dc.date.available | 2021-09-01T01:16:24Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 1613-4125 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62011 | - |
dc.description.abstract | Scope Punicalagin (PCG) is one of the most abundant phytochemicals found in pomegranates. The effects and mechanistic action of PCG on obesity and obesity-induced inflammatory and oxidant responses are investigated in vitro and in vivo. Methods and results The effect of PCG on adipogenesis is examined using Oil red O staining. The effects and mechanism of action of PCG on inflammatory responses are determined in adipocyte-conditioned medium (ACM)-cultured macrophages, a cell-to-cell contact system, and a transwell system. The effects of PCG on obesity and obesity-induced inflammatory/oxidant responses are examined in high-fat diet (HFD)-fed mice. PCG effectively suppresses lipid accumulation in adipocytes and adipocyte-induced inflammatory responses in adipocyte-macrophage co-culture systems. Small interfering RNA (siRNA) transfection indicates that the PCG-mediated anti-inflammatory effect is exerted via the nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1(Nrf2/Keap1) pathway. PCG administration results in a significant reduction in body and white adipose tissue (WAT) weights. PCG favorably regulates pro- and anti-inflammatory cytokines, downregulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B). Immunohistochemical (IHC) analysis demonstrates that PCG differentially modulates the distribution of complement component 3 receptor 4 subunit (CD11c) and cluster of differentiation 206 (CD206). PCG regulates the level of antioxidant and oxidant molecules by activating Nrf2/Keap1 signaling. Conclusions PCG ameliorates obesity and obesity-induced inflammatory responses via activation of Nrf2/Keap1 signaling, suggesting that PCG has potential as an oral agent to control obesity-mediated diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | MOLECULAR-MECHANISMS | - |
dc.subject | ANTIOXIDANT ACTIVITY | - |
dc.subject | JUICE | - |
dc.subject | HEALTH | - |
dc.subject | IMPACT | - |
dc.subject | NRF2 | - |
dc.subject | DIBENZOYLMETHANE | - |
dc.subject | EXTRACT | - |
dc.subject | INJURY | - |
dc.title | Punicalagin, a Pomegranate-Derived Ellagitannin, Suppresses Obesity and Obesity-Induced Inflammatory Responses Via the Nrf2/Keap1 Signaling Pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jo, Kyungae | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1002/mnfr.201900574 | - |
dc.identifier.scopusid | 2-s2.0-85071738100 | - |
dc.identifier.wosid | 000498507100001 | - |
dc.identifier.bibliographicCitation | MOLECULAR NUTRITION & FOOD RESEARCH, v.63, no.22 | - |
dc.relation.isPartOf | MOLECULAR NUTRITION & FOOD RESEARCH | - |
dc.citation.title | MOLECULAR NUTRITION & FOOD RESEARCH | - |
dc.citation.volume | 63 | - |
dc.citation.number | 22 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | JUICE | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | NRF2 | - |
dc.subject.keywordPlus | DIBENZOYLMETHANE | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordAuthor | co-culture | - |
dc.subject.keywordAuthor | HFD-fed mice | - |
dc.subject.keywordAuthor | Nrf2 | - |
dc.subject.keywordAuthor | Keap1 signaling | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | obesity-induced inflammatory response | - |
dc.subject.keywordAuthor | punicalagin | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.