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NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

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dc.contributor.authorAn, Lijun-
dc.contributor.authorLiang, Yue-
dc.contributor.authorYang, Xueyuan-
dc.contributor.authorWang, Huimei-
dc.contributor.authorZhang, Jie-
dc.contributor.authorTuerhong, Muhetaer-
dc.contributor.authorLi, Dihua-
dc.contributor.authorWang, Chunyan-
dc.contributor.authorLee, Dongho-
dc.contributor.authorXu, Jing-
dc.contributor.authorShuai, Ling-
dc.contributor.authorJin, Jin-
dc.contributor.authorGuo, Yuanqiang-
dc.date.accessioned2021-09-01T01:49:32Z-
dc.date.available2021-09-01T01:49:32Z-
dc.date.created2021-06-18-
dc.date.issued2019-11-
dc.identifier.issn0045-2068-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/62143-
dc.description.abstractTwo new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3-5), and seven known analogues (6-12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50, values less than 40 mu M. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectSTRUCTURALLY DIVERSE DITERPENOIDS-
dc.subjectANTI-NEUROINFLAMMATORY AGENTS-
dc.subjectINGOL-TYPE DITERPENES-
dc.subjectJATROPHANE DITERPENOIDS-
dc.subjectTIGLIANE DITERPENOIDS-
dc.subjectBIOLOGICAL EVALUATION-
dc.subjectMULTIDRUG-RESISTANCE-
dc.subjectROOTS-
dc.subjectLATEX-
dc.subjectESTERS-
dc.titleNO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Dongho-
dc.identifier.doi10.1016/j.bioorg.2019.103237-
dc.identifier.scopusid2-s2.0-85072252605-
dc.identifier.wosid000489699400060-
dc.identifier.bibliographicCitationBIOORGANIC CHEMISTRY, v.92-
dc.relation.isPartOfBIOORGANIC CHEMISTRY-
dc.citation.titleBIOORGANIC CHEMISTRY-
dc.citation.volume92-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusSTRUCTURALLY DIVERSE DITERPENOIDS-
dc.subject.keywordPlusANTI-NEUROINFLAMMATORY AGENTS-
dc.subject.keywordPlusINGOL-TYPE DITERPENES-
dc.subject.keywordPlusJATROPHANE DITERPENOIDS-
dc.subject.keywordPlusTIGLIANE DITERPENOIDS-
dc.subject.keywordPlusBIOLOGICAL EVALUATION-
dc.subject.keywordPlusMULTIDRUG-RESISTANCE-
dc.subject.keywordPlusROOTS-
dc.subject.keywordPlusLATEX-
dc.subject.keywordPlusESTERS-
dc.subject.keywordAuthorNO inhibitory effects-
dc.subject.keywordAuthorEuphorbia antiquorum-
dc.subject.keywordAuthorDiterpenoids-
dc.subject.keywordAuthorInflammation-
dc.subject.keywordAuthorMolecular docking-
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