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NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

Authors
An, LijunLiang, YueYang, XueyuanWang, HuimeiZhang, JieTuerhong, MuhetaerLi, DihuaWang, ChunyanLee, DonghoXu, JingShuai, LingJin, JinGuo, Yuanqiang
Issue Date
11월-2019
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
NO inhibitory effects; Euphorbia antiquorum; Diterpenoids; Inflammation; Molecular docking
Citation
BIOORGANIC CHEMISTRY, v.92
Indexed
SCIE
SCOPUS
Journal Title
BIOORGANIC CHEMISTRY
Volume
92
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/62143
DOI
10.1016/j.bioorg.2019.103237
ISSN
0045-2068
Abstract
Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3-5), and seven known analogues (6-12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50, values less than 40 mu M. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.
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