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Xylodon flaviporus-Derived Drimane Sesquiterpenoids That Inhibit Osteoclast Differentiation
- Authors
- Kwon, Jaeyoung; Lee, Hyaemin; Ryu, Seung Mok; Jang, Yeongseon; Kwon, Hak Cheol; Guo, Yuanqiang; Kang, Jong Soon; Kim, Jae-Jin; Lee, Dongho
- Issue Date
- Oct-2019
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.82, no.10, pp.2835 - 2841
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 82
- Number
- 10
- Start Page
- 2835
- End Page
- 2841
- ISSN
- 0163-3864
- Abstract
- The presence of excessive osteoclasts is a major factor in skeletal diseases. The present study aimed to discover osteoclast differentiation inhibitors from the basidiomycete Xylodon flaviporus. Seven new drimane sesquiterpenoids (1-7) and 7-ketoisodrimenin-5-ene (8) were obtained and characterized by various spectroscopic methods. The isolated compounds were evaluated for their inhibitory effects against receptor activator of nuclear factor-kappa-B ligand-induced osteoclastogenesis in mouse bone marrow macrophages. Compounds 1, 3, and 6 showed potent activities with IC50 values of 1.6, 0.9, and 2.1 mu M, respectively, while 4, 5, and 7 exhibited relatively weak activities with IC50 values of 10.7, 10.1, and 8.5 mu M, respectively.
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology