Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (Lactuca sativa) in a Rodent Model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyo-Won | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Choi, Hyeon-Son | - |
dc.contributor.author | Hong, Ki-Bae | - |
dc.contributor.author | Jo, Kyungae | - |
dc.date.accessioned | 2021-09-01T05:04:22Z | - |
dc.date.available | 2021-09-01T05:04:22Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62717 | - |
dc.description.abstract | This study was conducted to investigate the effects of the extracts of green romaine lettuce (GRE) on sleep enhancement. GRE contains 1071.7 and 199.2 mu g/g of extracts of lactucin and lactucopicrin, respectively, known as sleep enhancement substances. When 100 mg/kg of GRE was administered orally, sleep latency and duration time were significantly increased compared to controls (p < 0.05). Rapid eye movement (REM) sleep decreased with 100 mg/kg of GRE administration and non-REM (NREM) sleep also increased. There was no significant difference between REM and NREM among the oral GRE administration groups receiving 100, 120, and 160 mg/kg GRE. In the caffeine-induced insomnia model, total sleep time was significantly increased by 100 mg/kg GRE administration compared to the caffeine-treated group (p < 0.05). In addition, GRE inhibited the binding of [H-3]-flumazenil in a concentration-dependent manner, and affinity of both lactucin and lactucopicrin to gamma-aminobutyric acid (GABA)(A)-benzodiazepine (BDZ) receptor was 80.7% and 55.9%, respectively. Finally, in the pentobarbital-induced sleep mouse model, the sleep enhancement effect of GRE was inhibited by flumazenil, an antagonist of BDZ. Thus, these results demonstrate that GRE acts via a GABAergic mechanism to promote sleep in a rodent model. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.subject | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject | RAPID EYE-MOVEMENT | - |
dc.subject | PROMOTES SLEEP | - |
dc.subject | CAFFEINE | - |
dc.subject | MEDICINE | - |
dc.subject | INSOMNIA | - |
dc.subject | BEHAVIOR | - |
dc.subject | EXTRACT | - |
dc.subject | ANXIETY | - |
dc.title | Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (Lactuca sativa) in a Rodent Model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.contributor.affiliatedAuthor | Jo, Kyungae | - |
dc.identifier.doi | 10.1248/bpb.b19-00454 | - |
dc.identifier.scopusid | 2-s2.0-85072880632 | - |
dc.identifier.wosid | 000488888300016 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.42, no.10, pp.1726 - 1732 | - |
dc.relation.isPartOf | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.title | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 42 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1726 | - |
dc.citation.endPage | 1732 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | RAPID EYE-MOVEMENT | - |
dc.subject.keywordPlus | PROMOTES SLEEP | - |
dc.subject.keywordPlus | CAFFEINE | - |
dc.subject.keywordPlus | MEDICINE | - |
dc.subject.keywordPlus | INSOMNIA | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | ANXIETY | - |
dc.subject.keywordAuthor | Lactuca sativa | - |
dc.subject.keywordAuthor | sleep | - |
dc.subject.keywordAuthor | lactone | - |
dc.subject.keywordAuthor | pentobarbital | - |
dc.subject.keywordAuthor | electroencephalogram | - |
dc.subject.keywordAuthor | rodent model | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.