Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy
DC Field | Value | Language |
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dc.contributor.author | Zhang, Ruiping | - |
dc.contributor.author | Xu, Yuling | - |
dc.contributor.author | Zhang, Yi | - |
dc.contributor.author | Kim, Hyeong Seok | - |
dc.contributor.author | Sharma, Amit | - |
dc.contributor.author | Gao, Jing | - |
dc.contributor.author | Yang, Guangfu | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.contributor.author | Sun, Yao | - |
dc.date.accessioned | 2021-09-01T05:48:59Z | - |
dc.date.available | 2021-09-01T05:48:59Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-09-28 | - |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62826 | - |
dc.description.abstract | Small-molecule based multifunctional probes play significant roles in biomedical science and possess high clinical translational ability. However, the preparation of these promising probes without complicated synthetic procedures remains a challenging task. Herein, we rationally designed a high-performance DD-A-DD scaffold molecular dye (SYL) with an intrinsic multifunctional ability and then incorporated it into DSPE-mPEG5000 to facilely construct biocompatible NIR-II fluorescent and photoacoustic (PA) dual-modal theranostic nanoprobes (SYL NPs) (similar to 120 nm). In vivo studies confirmed that SYL NPs exhibited bright NIR-II fluorescence and PA signals in the tumor region with a promising signal to background ratio (S/B). Meanwhile, SYL NPs demonstrated significantly inhibited tumor growth under laser irradiation with no noticeable side effects. These promising results highlighted SYL NPs as a potential theranostic platform for cancer diagnosis (NIR-II region) and therapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | INFRARED-II FLUORESCENCE | - |
dc.subject | FLUOROPHORES | - |
dc.subject | CANCER | - |
dc.subject | NANOPARTICLES | - |
dc.subject | CONSTRUCTION | - |
dc.subject | NANOPROBES | - |
dc.subject | EMISSION | - |
dc.subject | PROBES | - |
dc.subject | WINDOW | - |
dc.title | Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1039/c9sc03504d | - |
dc.identifier.scopusid | 2-s2.0-85072596845 | - |
dc.identifier.wosid | 000487086900005 | - |
dc.identifier.bibliographicCitation | CHEMICAL SCIENCE, v.10, no.36, pp.8348 - 8353 | - |
dc.relation.isPartOf | CHEMICAL SCIENCE | - |
dc.citation.title | CHEMICAL SCIENCE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 36 | - |
dc.citation.startPage | 8348 | - |
dc.citation.endPage | 8353 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | INFRARED-II FLUORESCENCE | - |
dc.subject.keywordPlus | FLUOROPHORES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | CONSTRUCTION | - |
dc.subject.keywordPlus | NANOPROBES | - |
dc.subject.keywordPlus | EMISSION | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | WINDOW | - |
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