Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy
- Authors
- Zhang, Ruiping; Xu, Yuling; Zhang, Yi; Kim, Hyeong Seok; Sharma, Amit; Gao, Jing; Yang, Guangfu; Kim, Jong Seung; Sun, Yao
- Issue Date
- 28-9월-2019
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL SCIENCE, v.10, no.36, pp.8348 - 8353
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL SCIENCE
- Volume
- 10
- Number
- 36
- Start Page
- 8348
- End Page
- 8353
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/62826
- DOI
- 10.1039/c9sc03504d
- ISSN
- 2041-6520
- Abstract
- Small-molecule based multifunctional probes play significant roles in biomedical science and possess high clinical translational ability. However, the preparation of these promising probes without complicated synthetic procedures remains a challenging task. Herein, we rationally designed a high-performance DD-A-DD scaffold molecular dye (SYL) with an intrinsic multifunctional ability and then incorporated it into DSPE-mPEG5000 to facilely construct biocompatible NIR-II fluorescent and photoacoustic (PA) dual-modal theranostic nanoprobes (SYL NPs) (similar to 120 nm). In vivo studies confirmed that SYL NPs exhibited bright NIR-II fluorescence and PA signals in the tumor region with a promising signal to background ratio (S/B). Meanwhile, SYL NPs demonstrated significantly inhibited tumor growth under laser irradiation with no noticeable side effects. These promising results highlighted SYL NPs as a potential theranostic platform for cancer diagnosis (NIR-II region) and therapy.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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