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A chemodosimeter-modified carbon nanotube-field effect transistor: toward a highly selective and sensitive electrical sensing platform

Authors
Lee, Chang-SeukKim, Jong SeungKim, Tae Hyun
Issue Date
12-9월-2019
Publisher
ROYAL SOC CHEMISTRY
Citation
RSC ADVANCES, v.9, no.49, pp.28414 - 28420
Indexed
SCIE
SCOPUS
Journal Title
RSC ADVANCES
Volume
9
Number
49
Start Page
28414
End Page
28420
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/62879
DOI
10.1039/c9ra04656a
ISSN
2046-2069
Abstract
We present a carbon nanotube-field effect transistor (CNT-FET) biosensor which first implements the chemodosimeter sensing principle in CNT nanoelectronics. We experimentally illustrate the specific molecular interplay that the cysteine-selective chemodosimeter immobilized on the CNT surface can specifically interact with cysteine, which leads to the chemical transformation of the chemodosimeter. Since the chemical transformation of the chemodosimeter can disrupt the charge distribution in the vicinity of the CNT surface, the carrier equilibrium in CNT might be altered, and manifested by the conductivity change of CNT-FET. The real-time conductance measurements show our biosensor is capable of label-free, rapid, highly selective and ultrasensitive detection of cysteine with a detection limit down to 0.45 fM. These results first verify the signaling principle competency of chemical transformation of the chemodosimeter in CNT electronic sensors. Combined with the advantages of the highly selective chemodosimeter and sensitive CNT-FET, the excellent performance of our sensor indicates its promising prospect as a valuable tool for developing highly sensitive and selective sensing platforms in practical application.
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