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Enhanced bioavailability of alpha-lipoic acid by complex formation with octenylsuccinylated high-amylose starch

Authors
Li, Yi-XuanKim, Yeon-JiReddy, Chagam KoteswaraLee, Sung-JoonLim, Seung-Taik
Issue Date
1-9월-2019
Publisher
ELSEVIER SCI LTD
Keywords
Alpha-lipoic acid; Bioavailability; Cellular absorption; Encapsulation; Octenylsuccinylated high-amylose starch; V-type complex
Citation
CARBOHYDRATE POLYMERS, v.219, pp.39 - 45
Indexed
SCIE
SCOPUS
Journal Title
CARBOHYDRATE POLYMERS
Volume
219
Start Page
39
End Page
45
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/62940
DOI
10.1016/j.carbpol.2019.04.082
ISSN
0144-8617
Abstract
An aqueous dispersion of alpha-lipoic acid (ALA) using octenylsuccinic anhydride-modified high-amylose starch (OS) was prepared, and thermal stability and cellular bioavailability of ALA were compared with those prepared using native high-amylose starch (HA) and beta-cyclodextrin (beta-CD). The ALA was homogeneously dispersed via the encapsulation of V-type amylose helices. In comparison with HA and beta-CD, OS exhibited a higher ALA absorption in Caco-2 cells, indicating the OS facilitated the intestinal epithelial transport of ALA. Oral administration of the encapsulated ALA in-vivo resulted in a higher maximum ALA plasma concentration and extended the terminal half-life by 30-40%. The area under the plasma concentration vs. time for the administration of ALA complexed by OS was 50% larger than that by HA, indicating the effectiveness of OS in enhancing the oral bioavailability of ALA. These results indicate that OS is an efficient carrier for ALA in oral delivery and bioavailability.
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Lee, Sung Joon
생명과학대학 (식품공학과)
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