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Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities
- Authors
- Shuo, Yuan; Zhang, Chenyue; Yang, Xueyuan; Liu, Feng; Zhang, Qi; Li, Annan; Ma, Jun; Lee, Dongho; Ohizumi, Yasushi; Guo, Yuanqiang
- Issue Date
- Sep-2019
- Publisher
- SPRINGER JAPAN KK
- Keywords
- Casearia kurzii; Clerodane diterpenoids; Cytotoxic activities; Apoptosis; Cell cycle
- Citation
- JOURNAL OF NATURAL MEDICINES, v.73, no.4, pp.826 - 833
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL MEDICINES
- Volume
- 73
- Number
- 4
- Start Page
- 826
- End Page
- 833
- ISSN
- 1340-3443
- Abstract
- A search for bioactive natural products as anticancer lead compounds resulted in the isolation of one previously undescribed and three known clerodane diterpenoids (1-4) from Casearia kurzii. The structures of these compounds were established by analysis of their NMR, MS, and electronic circular dichroism data. The cytotoxic activities of four compounds against three human cancer cell lines were evaluated. Compound 2 was found to be the most active with an IC50 value of 4.1 mu M against HeLa cells, and was selected to investigate the possible cytotoxic mechanism. [GRAPHICS] .
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology