Non-glycosidic iridoids from the roots of Patrinia scabra and their nitric oxide production inhibitory effects
- Authors
- Lee, Da Hye; Shin, Ji-Sun; Lee, Jin Su; Kang, Shin-Young; Han, Hee-Soo; Ryu, Seung Mok; Lee, Kyung-Tae; Lee, Dongho; Jang, Dae Sik
- Issue Date
- Sep-2019
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Patrinia scabra; Valerianaceae; Iridoid; Patriscabrin; Nitric oxide
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.42, no.9, pp.766 - 772
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 42
- Number
- 9
- Start Page
- 766
- End Page
- 772
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/63428
- DOI
- 10.1007/s12272-019-01117-0
- ISSN
- 0253-6269
- Abstract
- Phytochemical investigation on the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new non-glycosidic iridoids, patriscabrins F-J (1-5), along with a known iridoid 11-ethoxyviburtinal (6). The structures of the new compounds 1-5 were determined by interpretation of spectroscopic data, particularly by 1D- and 2D-NMR and ECD studies. Thereafter, the isolates 1-6 were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, patriscabrin F (1) exhibited the most potent inhibitory effect with observed IC50 value of 14.1 mu M. In addition, patriscabrin G (2) and 11-ethoxyviburtinal (6) showed IC50 values 24.6 and 35.5 mu M, respectively.
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