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Mycoplasma exploits mammalian tunneling nanotubes for cell-to-cell dissemination

Authors
Kim, Bong-WooLee, Jae-SeonKo, Young-Gyu
Issue Date
31-8월-2019
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Keywords
Fibroblast; Mycoplasma; Rac1; Tunneling nanotube
Citation
BMB REPORTS, v.52, no.8, pp.490 - 495
Indexed
SCIE
SCOPUS
KCI
Journal Title
BMB REPORTS
Volume
52
Number
8
Start Page
490
End Page
495
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/63463
DOI
10.5483/BMBRep.2019.52.8.243
ISSN
1976-6696
Abstract
Using tunneling nanotubes (TNTs), various pathological molecules and viruses disseminate to adjacent cells intercellularly. Here, we show that the intracellular invasion of Mycoplasma hyorhinis induces the formation of actin-and tubulin-based TNTs in various mammalian cell lines. M. hyorhinis was found in TNTs generated by M. hyorhinis infection in NIH3T3 cells. Because mycoplasma-free recipient cells received mycoplasmas from M. hyorhinis-infected donor cells in a mixed co-culture system and not a spatially separated co-culture system, direct cell-to-cell contact via TNTs was necessary for the intracellular dissemination of M. hyorhinis. The activity of Rac1, which is a small GTP binding protein, was increased by the intracellular invasion of M. hyorhinis, and its pharmacological and genetic inhibition prevented M. hyorhinis infection-induced TNT generation in NIH3T3 cells. The pharmacological and genetic inhibition of Rac1 also reduced the cell-to-cell dissemination of M. hyorhinis. Based on these data, we conclude that intracellular invasion of M. hyorhinis induces the formation of TNTs, which are used for the cell-to-cell dissemination of M. hyorhinis.
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