Nanoenabled Direct Contact Interfacing of Syringe-Injectable Mesh Electronics
DC Field | Value | Language |
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dc.contributor.author | Lee, Jung Min | - |
dc.contributor.author | Hong, Guosong | - |
dc.contributor.author | Lin, Dingchang | - |
dc.contributor.author | Schuhmann, Thomas G., Jr. | - |
dc.contributor.author | Sullivan, Andrew T. | - |
dc.contributor.author | Viyeros, Robert D. | - |
dc.contributor.author | Park, Hong-Gyu | - |
dc.contributor.author | Lieber, Charles M. | - |
dc.date.accessioned | 2021-09-01T11:00:36Z | - |
dc.date.available | 2021-09-01T11:00:36Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-08 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/64023 | - |
dc.description.abstract | Polymer-based electronics with low bending stiffnesses and high flexibility, including recently reported macroporous syringe-injectable mesh electronics, have shown substantial promise for chronic studies of neural circuitry in the brains of live animals. A central challenge for exploiting these highly flexible materials for in vivo studies has centered on the development of efficient input/output (I/O) connections to an external interface with high yield, low bonding resistance, and long-term stability. Here we report a new paradigm applied to the challenging case of injectable mesh electronics that exploits the high flexibility of nanoscale thickness two-sided metal I/O pads that can deform and contact standard interface cables in high yield with long-term electrical stability. First, we describe the design and facile fabrication of two-sided metal I/O pads that allow for contact without regard to probe orientation. Second, systematic studies of the contact resistance as a function of I/O pad design and mechanical properties demonstrate the key role of the I/O pad bending stiffness in achieving low-resistance stable contacts. Additionally, computational studies provide design rules for achieving high-yield multiplexed contact interfacing in the case of angular misalignment such that adjacent channels are not shorted. Third, the in vitro measurement of 32-channel mesh electronics probes bonded to interface cables using the direct contact method shows a reproducibly high yield of electrical connectivity. Finally, in vivo experiments with 32-channel mesh electronics probes implanted in live mice demonstrate the chronic stability of the direct contact interface, enabling consistent tracking of single unit neural activity over at least 2 months without a loss of channel recording. The direct contact interfacing methodology paves the way for scalable long-term connections of multiplexed mesh electronics neural probes for neural recording and modulation and moreover could be used to facilitate a scalable interconnection of other flexible electronics in biological studies and therapeutic applications. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | BRAIN | - |
dc.subject | ELECTROPHYSIOLOGY | - |
dc.subject | REPRESENTATION | - |
dc.subject | RECORDINGS | - |
dc.subject | PROBES | - |
dc.subject | FILMS | - |
dc.title | Nanoenabled Direct Contact Interfacing of Syringe-Injectable Mesh Electronics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hong-Gyu | - |
dc.identifier.doi | 10.1021/acs.nanolett.9b03019 | - |
dc.identifier.scopusid | 2-s2.0-85070664708 | - |
dc.identifier.wosid | 000481563800130 | - |
dc.identifier.bibliographicCitation | NANO LETTERS, v.19, no.8, pp.5818 - 5826 | - |
dc.relation.isPartOf | NANO LETTERS | - |
dc.citation.title | NANO LETTERS | - |
dc.citation.volume | 19 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 5818 | - |
dc.citation.endPage | 5826 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | ELECTROPHYSIOLOGY | - |
dc.subject.keywordPlus | REPRESENTATION | - |
dc.subject.keywordPlus | RECORDINGS | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | FILMS | - |
dc.subject.keywordAuthor | Double-sided metal input/output | - |
dc.subject.keywordAuthor | flexible input/output | - |
dc.subject.keywordAuthor | multiplexed electrophysiology | - |
dc.subject.keywordAuthor | biocompatible neural probes | - |
dc.subject.keywordAuthor | chronic neural interface | - |
dc.subject.keywordAuthor | flexible electronics | - |
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