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Nanoenabled Direct Contact Interfacing of Syringe-Injectable Mesh Electronics

Authors
Lee, Jung MinHong, GuosongLin, DingchangSchuhmann, Thomas G., Jr.Sullivan, Andrew T.Viyeros, Robert D.Park, Hong-GyuLieber, Charles M.
Issue Date
8월-2019
Publisher
AMER CHEMICAL SOC
Keywords
Double-sided metal input/output; flexible input/output; multiplexed electrophysiology; biocompatible neural probes; chronic neural interface; flexible electronics
Citation
NANO LETTERS, v.19, no.8, pp.5818 - 5826
Indexed
SCIE
SCOPUS
Journal Title
NANO LETTERS
Volume
19
Number
8
Start Page
5818
End Page
5826
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/64023
DOI
10.1021/acs.nanolett.9b03019
ISSN
1530-6984
Abstract
Polymer-based electronics with low bending stiffnesses and high flexibility, including recently reported macroporous syringe-injectable mesh electronics, have shown substantial promise for chronic studies of neural circuitry in the brains of live animals. A central challenge for exploiting these highly flexible materials for in vivo studies has centered on the development of efficient input/output (I/O) connections to an external interface with high yield, low bonding resistance, and long-term stability. Here we report a new paradigm applied to the challenging case of injectable mesh electronics that exploits the high flexibility of nanoscale thickness two-sided metal I/O pads that can deform and contact standard interface cables in high yield with long-term electrical stability. First, we describe the design and facile fabrication of two-sided metal I/O pads that allow for contact without regard to probe orientation. Second, systematic studies of the contact resistance as a function of I/O pad design and mechanical properties demonstrate the key role of the I/O pad bending stiffness in achieving low-resistance stable contacts. Additionally, computational studies provide design rules for achieving high-yield multiplexed contact interfacing in the case of angular misalignment such that adjacent channels are not shorted. Third, the in vitro measurement of 32-channel mesh electronics probes bonded to interface cables using the direct contact method shows a reproducibly high yield of electrical connectivity. Finally, in vivo experiments with 32-channel mesh electronics probes implanted in live mice demonstrate the chronic stability of the direct contact interface, enabling consistent tracking of single unit neural activity over at least 2 months without a loss of channel recording. The direct contact interfacing methodology paves the way for scalable long-term connections of multiplexed mesh electronics neural probes for neural recording and modulation and moreover could be used to facilitate a scalable interconnection of other flexible electronics in biological studies and therapeutic applications.
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