Obesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians
DC Field | Value | Language |
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dc.contributor.author | Nam, Ga Eun | - |
dc.contributor.author | Cho, Kyung Hwan | - |
dc.contributor.author | Han, Kyungdo | - |
dc.contributor.author | Kim, Chul Min | - |
dc.contributor.author | Han, Byoungduck | - |
dc.contributor.author | Cho, Sung Jung | - |
dc.contributor.author | Jung, Seung Jin | - |
dc.contributor.author | Kwon, Yeongkeun | - |
dc.contributor.author | Kim, Yang Hyun | - |
dc.contributor.author | Kim, Do Hoon | - |
dc.contributor.author | Kim, Seon Mee | - |
dc.contributor.author | Choi, Youn Seon | - |
dc.contributor.author | Roh, Yong Kyun | - |
dc.contributor.author | Park, Yong Gyu | - |
dc.date.accessioned | 2021-09-01T11:03:45Z | - |
dc.date.available | 2021-09-01T11:03:45Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-07-30 | - |
dc.identifier.issn | 0007-0920 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/64052 | - |
dc.description.abstract | BACKGROUND: Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. METHODS: We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 2009-2012 and performed multivariable Cox proportional hazards regression analyses. RESULTS: During 5.4 years of follow-up, 18,036 cases of kidney cancer were recorded, and cumulative incidence was 0.12%. General and abdominal obesity were associated with 1.32-fold increased risk of kidney cancer compared with groups without either obesity status. Underweight individuals showed decreased adjusted hazard ratio (HR) for kidney cancer (0.76, 95% confidence interval: 0.68-0.85) compared to those with normal body mass index (BMI), while the HRs increased among individuals with BMI 23-24.9 kg/m(2) (1.23, 1.18-1.28), 25-29.9 kg/m(2) (1.41, 1.36-1.46) and >= 30 kg/m(2) (1.77, 1.65-1.90) (P for trend < 0.001). HRs of kidney cancer increased with increasing waist circumference (WC) (P for trend < 0.001). Compared to non-obese condition, the coexistence of general and abdominal obesity increased the HR (1.45, 1.40-1.50). CONCLUSIONS: This study demonstrated positive associations of BMI and WC with kidney cancer risk. General and abdominal obesity may be risk factors of kidney cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | RENAL-CELL CARCINOMA | - |
dc.subject | BODY-MASS INDEX | - |
dc.subject | WAIST CIRCUMFERENCE | - |
dc.subject | PHYSICAL-ACTIVITY | - |
dc.subject | METAANALYSIS | - |
dc.subject | EPIDEMIOLOGY | - |
dc.subject | ENDOMETRIAL | - |
dc.subject | ASSOCIATION | - |
dc.subject | MECHANISMS | - |
dc.subject | NUTRITION | - |
dc.title | Obesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Ga Eun | - |
dc.contributor.affiliatedAuthor | Cho, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | Kwon, Yeongkeun | - |
dc.contributor.affiliatedAuthor | Kim, Yang Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Do Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Seon Mee | - |
dc.contributor.affiliatedAuthor | Choi, Youn Seon | - |
dc.identifier.doi | 10.1038/s41416-019-0500-z | - |
dc.identifier.scopusid | 2-s2.0-85067868413 | - |
dc.identifier.wosid | 000477837000011 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF CANCER, v.121, no.3, pp.271 - 277 | - |
dc.relation.isPartOf | BRITISH JOURNAL OF CANCER | - |
dc.citation.title | BRITISH JOURNAL OF CANCER | - |
dc.citation.volume | 121 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 271 | - |
dc.citation.endPage | 277 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | RENAL-CELL CARCINOMA | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | WAIST CIRCUMFERENCE | - |
dc.subject.keywordPlus | PHYSICAL-ACTIVITY | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | ENDOMETRIAL | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | NUTRITION | - |
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