Obesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians
- Authors
- Nam, Ga Eun; Cho, Kyung Hwan; Han, Kyungdo; Kim, Chul Min; Han, Byoungduck; Cho, Sung Jung; Jung, Seung Jin; Kwon, Yeongkeun; Kim, Yang Hyun; Kim, Do Hoon; Kim, Seon Mee; Choi, Youn Seon; Roh, Yong Kyun; Park, Yong Gyu
- Issue Date
- 30-7월-2019
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- BRITISH JOURNAL OF CANCER, v.121, no.3, pp.271 - 277
- Indexed
- SCIE
SCOPUS
- Journal Title
- BRITISH JOURNAL OF CANCER
- Volume
- 121
- Number
- 3
- Start Page
- 271
- End Page
- 277
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/64052
- DOI
- 10.1038/s41416-019-0500-z
- ISSN
- 0007-0920
- Abstract
- BACKGROUND: Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. METHODS: We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 2009-2012 and performed multivariable Cox proportional hazards regression analyses. RESULTS: During 5.4 years of follow-up, 18,036 cases of kidney cancer were recorded, and cumulative incidence was 0.12%. General and abdominal obesity were associated with 1.32-fold increased risk of kidney cancer compared with groups without either obesity status. Underweight individuals showed decreased adjusted hazard ratio (HR) for kidney cancer (0.76, 95% confidence interval: 0.68-0.85) compared to those with normal body mass index (BMI), while the HRs increased among individuals with BMI 23-24.9 kg/m(2) (1.23, 1.18-1.28), 25-29.9 kg/m(2) (1.41, 1.36-1.46) and >= 30 kg/m(2) (1.77, 1.65-1.90) (P for trend < 0.001). HRs of kidney cancer increased with increasing waist circumference (WC) (P for trend < 0.001). Compared to non-obese condition, the coexistence of general and abdominal obesity increased the HR (1.45, 1.40-1.50). CONCLUSIONS: This study demonstrated positive associations of BMI and WC with kidney cancer risk. General and abdominal obesity may be risk factors of kidney cancer.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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