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Quantitative Analysis on Cellular Uptake of Clustered Ferrite Magnetic Nanoparticles

Authors
Kim, Yu JinPark, Bum ChulChoi, Young SooKo, Min JunKim, Young Keun
Issue Date
7월-2019
Publisher
KOREAN INST METALS MATERIALS
Keywords
Magnetic nanoparticle; Ferrite; Biomolecule; Cellular uptake; Quantitative analysis
Citation
ELECTRONIC MATERIALS LETTERS, v.15, no.4, pp.471 - 480
Indexed
SCIE
SCOPUS
KCI
Journal Title
ELECTRONIC MATERIALS LETTERS
Volume
15
Number
4
Start Page
471
End Page
480
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/64204
DOI
10.1007/s13391-019-00141-y
ISSN
1738-8090
Abstract
Due to their ability to be internalized into cells by endocytosis through cell membranes, the application of nanoparticles in therapeutic and diagnostic fields has received much interest. In particular, ferrite magnetic nanoparticles (MNPs) are widely used as reagents for medical care, including in vitro magnetic separation, T2-weighted magnetic resonance imaging, magnetic hyperthermia therapy, and as drug delivery systems. However, little is known about the quantitative analysis of the cellular uptake of MNPs by the interaction of particle surfaces with biomolecules. Here, we quantitatively analyze the intracellular uptakes of 30nm Fe- and Mn-ferrite MNPs. We confirm that the magnetic properties of MNPs change according to their microstructure and quantitatively analyze nanoparticle internalization in breast cell lines (MCF10A, MCF7, and MDA-MB-231) by measuring the magnetic moment using a vibrating sample magnetometer. Finally, we examine the effect of nanoparticle microstructure on cellular uptake in terms of the interaction between the nanoparticles and biomolecules. [GRAPHICS] .
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공과대학 (신소재공학부)
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