Parthenolide, a feverfew-derived phytochemical, ameliorates obesity and obesity-induced inflammatory responses via the Nrf2/Keap1 pathway
DC Field | Value | Language |
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dc.contributor.author | Kim, Chae Young | - |
dc.contributor.author | Kang, Bobin | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Choi, Hyeon-Son | - |
dc.date.accessioned | 2021-09-01T12:53:37Z | - |
dc.date.available | 2021-09-01T12:53:37Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 1043-6618 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/64261 | - |
dc.description.abstract | Parthenolide (PL) is one of the most abundant sesquiterpene lactones found in the plant feverfew (Tanacetum parthenium (L.) Sch.Bip.). PL was investigated for its effect on obesity and obesity-induced inflammatory/oxidant responses in vitro and in vivo. An obesity-induced inflammatory response was induced in various co-culture systems using adipocytes (3T3-L1) and macrophages (RAW264.7) in vitro and the effect of PL and its mechanism of action were determined. PL effectively suppressed the adiposity-induced inflammatory responses by down-regulating IL-6 (40-42%) and MCP-1 (26-37%) in 3T3-CM-cultured macrophages and contact co-culture system. PL also favorably regulated the dysregulations of adiponectin and resistin in macrophage-conditioned medium (RAW-CM)-cultured adipocytes. In transwell system of adipocyte and macrophage, PL was shown to upregulated Nrf2 and its target molecule, HO-1 by promoting nuclear translocation of Nrf2. In particular, in siRNA knockdown study, the PL-mediated anti-inflammatory response was exerted via the Nrf2/Keap1 pathway. In animal study using high-fat diet (HFD)-fed mice, PL-administered mice showed a significant reduction in body weight and white adipose tissues (WATs). This PL-mediated anti-obese effect was connected to anti-inflammatory responses with the regulation of inflammatory cytokines, and the downregulation of NF-kappa B and MAPKs. Furthermore, PL differentially modulated CD11c and CD206, which are pro-/anti-inflammatory phenotypes of ATMs, in stroma vascular fraction (SVF) and immunohistochemistry (IHC) staining analyses. PL also regulated the level of (anti)oxidant molecules with the activation of Nrf2/Keap1signaling. Taken together, PL inhibited obesity and obesity-induced inflammatory responses via the activation of Nrf2/Keap1 signaling, indicating a potential of PL as a functional agent to control obesity-related diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | HEME OXYGENASE-1 | - |
dc.subject | MOLECULAR-MECHANISMS | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | NRF2 | - |
dc.subject | CANCER | - |
dc.title | Parthenolide, a feverfew-derived phytochemical, ameliorates obesity and obesity-induced inflammatory responses via the Nrf2/Keap1 pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1016/j.phrs.2019.104259 | - |
dc.identifier.scopusid | 2-s2.0-85065843353 | - |
dc.identifier.wosid | 000475721100002 | - |
dc.identifier.bibliographicCitation | PHARMACOLOGICAL RESEARCH, v.145 | - |
dc.relation.isPartOf | PHARMACOLOGICAL RESEARCH | - |
dc.citation.title | PHARMACOLOGICAL RESEARCH | - |
dc.citation.volume | 145 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | HEME OXYGENASE-1 | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | NRF2 | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | Parthenolide | - |
dc.subject.keywordAuthor | Co-culture | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Obesity-induced inflammatory response | - |
dc.subject.keywordAuthor | Nrf2/Keap1 signaling | - |
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