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Identification of Two New Phenanthrenes from Dendrobii Herba and Their Cytotoxicity towards Human Hypopharynx Squamous Carcinoma Cell (FaDu)
- Authors
- Nam, Bomi; Ryu, Seung Mok; Lee, Dongho; Jung, Chan-Hun; Jin, Chang Hyun; Kim, Jin-Baek; Lee, Ik-Soo; Han, Ah-Reum
- Issue Date
- 2-6월-2019
- Publisher
- MDPI
- Keywords
- Dendrobii Herba; (1R,2R)-1,7-hydroxy-2,8-methoxy-2,3-dihydrophenanthrene-4(1H)-one; 2,7-dihydroxy-phenanthrene-1,4-dione; cytotoxicity; FaDu human hypopharynx squamous carcinoma cell
- Citation
- MOLECULES, v.24, no.12
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULES
- Volume
- 24
- Number
- 12
- ISSN
- 1420-3049
- Abstract
- Two new phenanthrenes, (1R,2R)-1,7-hydroxy-2,8-methoxy-2,3-dihydrophenanthrene-4(1H)-one (1) and 2,7-dihydroxy-phenanthrene-1,4-dione (2), were isolated from the ethyl acetate-soluble fraction of Dendrobii Herba, together with seven known phenanthrenes (3-9), two bibenzyls (10-12), and a lignan (13). Structures of 1 and 2 were elucidated by analyzing one-dimensional (1D) and two-dimensional (2D)-NMR and High-resolution electrospray ionization mass spectra (HR-ESI-MS) data. The absolute configuration of compound 1 was confirmed by the circular dichroism (CD) spectroscopic method. In cytotoxicity assay using FaDu human hypopharynx squamous carcinoma cell line, compounds 3-6, 8, 10, and 12 showed activities, with IC50 values that ranged from 2.55 to 17.70 mu M.
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