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A Schiff Base Fluorescence Enhancement Probe for Fe(III) and Its Sensing Applications in Cancer Cells
- Authors
- Kim, Na Hee; Lee, Junho; Park, Sungnam; Jung, Junyang; Kim, Dokyoung
- Issue Date
- 1-6월-2019
- Publisher
- MDPI
- Keywords
- fluorescent probe; Schiff base probe; iron ion sensing; D-A type fluorophore; bioimaging
- Citation
- SENSORS, v.19, no.11
- Indexed
- SCIE
SCOPUS
- Journal Title
- SENSORS
- Volume
- 19
- Number
- 11
- ISSN
- 1424-8220
- Abstract
- We report a new Schiff base fluorescent probe which senses ferric ion, Fe(III), with a significant fluorescence enhancement response. The probe showed high sensitivity (0.8 ppb), and fast response time (<10 s) of Fe(III) in aqueous media. In addition, the probe showed the ability to sense Fe(III) in a HeLa cancer cell line, with very low cytotoxicity. As a new bio-imaging probe for Fe(III), it gave bright fluorescent images in confocal laser scanning microscopy (CLSM).
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