Glycopentanolones A-D, four new geranylated quinolone alkaloids from Glycosmis pentaphylla
DC Field | Value | Language |
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dc.contributor.author | Choi, Yun-Hyeok | - |
dc.contributor.author | Seo, Changon | - |
dc.contributor.author | Jeong, Wonsik | - |
dc.contributor.author | Lee, Ji Eun | - |
dc.contributor.author | Lee, Jae Yeon | - |
dc.contributor.author | Ahn, Eun-Kyung | - |
dc.contributor.author | Kang, Jae-Shin | - |
dc.contributor.author | Lee, Jae-Ho | - |
dc.contributor.author | Choi, Chun Whan | - |
dc.contributor.author | Oh, Joa Sub | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Hong, Seong Su | - |
dc.date.accessioned | 2021-09-01T14:29:38Z | - |
dc.date.available | 2021-09-01T14:29:38Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 0045-2068 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/65201 | - |
dc.description.abstract | The ethanolic extract obtained from the stems of Glycosmis pentaphylla was found to suppress antigen-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells. Four new geranylated 2-quinolone alkaloids, named glycopentanolones A-D (1-4), and 12 known metabolites (5-16) were isolated from the ethanolic extract from the stems of G. pentaphylla using bioassay-guided fractionation. Their structures were elucidated by a combination of 1D and 2D NMR, and HRESI-MS. The inhibitory effects of the isolated constituents on beta-hexosaminidase release from RBL-2H3 cells were examined, and compounds 1, 5, 8 and 11 exhibited potent inhibitory activity with IC50, values between 0.05 and 4.28 mu M. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | DEGRANULATION | - |
dc.subject | INHIBITORS | - |
dc.subject | INDOLE | - |
dc.subject | FLAVONOIDS | - |
dc.subject | GLYCOSIDES | - |
dc.subject | FLAVANOLS | - |
dc.subject | COMPOUND | - |
dc.subject | EXTRACT | - |
dc.subject | ESTERS | - |
dc.subject | STEMS | - |
dc.title | Glycopentanolones A-D, four new geranylated quinolone alkaloids from Glycosmis pentaphylla | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.1016/j.bioorg.2019.03.069 | - |
dc.identifier.scopusid | 2-s2.0-85063680390 | - |
dc.identifier.wosid | 000469026400068 | - |
dc.identifier.bibliographicCitation | BIOORGANIC CHEMISTRY, v.87, pp.714 - 719 | - |
dc.relation.isPartOf | BIOORGANIC CHEMISTRY | - |
dc.citation.title | BIOORGANIC CHEMISTRY | - |
dc.citation.volume | 87 | - |
dc.citation.startPage | 714 | - |
dc.citation.endPage | 719 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | DEGRANULATION | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | INDOLE | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.subject.keywordPlus | FLAVANOLS | - |
dc.subject.keywordPlus | COMPOUND | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | ESTERS | - |
dc.subject.keywordPlus | STEMS | - |
dc.subject.keywordAuthor | Glycosmis pentaphylla | - |
dc.subject.keywordAuthor | 2-Quinolone alkaloid | - |
dc.subject.keywordAuthor | Glycopentanolone | - |
dc.subject.keywordAuthor | beta-hexosaminidase | - |
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