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Glycopentanolones A-D, four new geranylated quinolone alkaloids from Glycosmis pentaphylla
- Authors
- Choi, Yun-Hyeok; Seo, Changon; Jeong, Wonsik; Lee, Ji Eun; Lee, Jae Yeon; Ahn, Eun-Kyung; Kang, Jae-Shin; Lee, Jae-Ho; Choi, Chun Whan; Oh, Joa Sub; Lee, Dongho; Hong, Seong Su
- Issue Date
- 6월-2019
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Glycosmis pentaphylla; 2-Quinolone alkaloid; Glycopentanolone; beta-hexosaminidase
- Citation
- BIOORGANIC CHEMISTRY, v.87, pp.714 - 719
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC CHEMISTRY
- Volume
- 87
- Start Page
- 714
- End Page
- 719
- ISSN
- 0045-2068
- Abstract
- The ethanolic extract obtained from the stems of Glycosmis pentaphylla was found to suppress antigen-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells. Four new geranylated 2-quinolone alkaloids, named glycopentanolones A-D (1-4), and 12 known metabolites (5-16) were isolated from the ethanolic extract from the stems of G. pentaphylla using bioassay-guided fractionation. Their structures were elucidated by a combination of 1D and 2D NMR, and HRESI-MS. The inhibitory effects of the isolated constituents on beta-hexosaminidase release from RBL-2H3 cells were examined, and compounds 1, 5, 8 and 11 exhibited potent inhibitory activity with IC50, values between 0.05 and 4.28 mu M.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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