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Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS
- Authors
- Dong, Bangjian; An, Lijun; Yang, Xueyuan; Zhang, Xuke; Zhang, Jie; Tuerhong, Muhetaer; Jin, Da-Qing; Ohizumi, Yasushi; Lee, Dongho; Xu, Jing; Guo, Yuanqiang
- Issue Date
- Jun-2019
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Physalis peruviana; Withanolides; NO inhibitors; Molecular docking; iNOS
- Citation
- BIOORGANIC CHEMISTRY, v.87, pp.585 - 593
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC CHEMISTRY
- Volume
- 87
- Start Page
- 585
- End Page
- 593
- ISSN
- 0045-2068
- Abstract
- A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new with-anolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology