NO inhibitory phytochemicals as potential anti-inflammatory agents from the twigs of Trigonostemon heterophyllus
- Authors
- Xi, Yaru; An, Lijun; Yang, Xueyuan; Song, Ziteng; Zhang, Jie; Tuerhong, Muhetaer; Jin, Da-Qing; Ohizumi, Yasushi; Lee, Dongho; Xu, Jing; Guo, Yuanqiang
- Issue Date
- Jun-2019
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- NO inhibitors; Trigonostemon heterophyllus; Cleistanthane diterpenoids; Inflammation; Molecular docking
- Citation
- BIOORGANIC CHEMISTRY, v.87, pp.417 - 424
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC CHEMISTRY
- Volume
- 87
- Start Page
- 417
- End Page
- 424
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/65211
- DOI
- 10.1016/j.bioorg.2019.03.029
- ISSN
- 0045-2068
- Abstract
- Studies on the relationship of nitric oxide (NO) and inflammation have revealed that compounds with NO inhibitory effects are potentially useful for inflammation and related inflammatory disorders. A phytochemical investigation to obtain new NO inhibitors resulted in the isolation of two new cleistanthane diterpenoids (1 and 2) and 11 known terpenoids (3-13) from Trigonostemon heterophyllus. The structures of these terpenoids were established by analysis of their NMR, MS, and electronic circular dichroism (ECD) data. Compounds 1 and 2 possess rare 3,4-seco-cleistanthane diterpenoid skeletons. All of the isolates were evaluated biologically for their NO inhibitory effects in lipopolysaccharide (LPS)-induced murine microglial BV-2 cells and compounds 1, 6, and 8-10 showed strong NO inhibitory effects with IC50 values less than 40 mu M. Using Western blotting experiments and molecular docking, the possible mechanism of NO inhibition was investigated.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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