The usefulness of C-reactive protein and procalcitonin to predict prognosis in septic shock patients: A multicenter prospective registry-based observational study
- Authors
- Ryoo, Seung Mok; Han, Kap Su; Ahn, Shin; Shin, Tae Gun; Hwang, Sung Yeon; Chung, Sung Phil; Hwang, Yoon Jung; Park, Yoo Seok; Jo, You Hwan; Chang, Hyung Lan; Suh, Gil Joon; You, Kyoung Min; Kang, Gu Hyun; Choi, Sung-Hyuk; Lim, Tae Ho; Kim, Won Young; Kim, Youn-Jung; Lee, Sung Woo; Jo, Ik Joon; Kim, Min Joung; Kwon, Woon Yong; Lee, Hui Jai; Shin, Jong Hwan; Ko, Byuk Sung
- Issue Date
- 29-4월-2019
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v.9
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 9
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/65959
- DOI
- 10.1038/s41598-019-42972-7
- ISSN
- 2045-2322
- Abstract
- The objective of this study was to evaluate the prognostic value of C-reactive protein (CRP), procalcitonin (PCT), and their combination for mortality in patients with septic shock. This multicenter, prospective, observational study was conducted between November 2015 and December 2017. A total of 1,772 septic shock patients were included, and the overall 28-day mortality was 20.7%. Although both CRP and PCT were elevated in the non-survivor group, only CRP had statistical significance (11.9 mg/dL vs. 14.7 mg/dL, p = 0.003, 6.4 ng/mL vs. 8.2 ng/mL, p = 0.508). Multivariate analysis showed that CRP and PCT were not independent prognostic markers. In the subgroup analysis of the CRP and PCT combination matrix using their optimal cut-off values (CRP 14.0 mg/dL, PCT 17.0 ng/dL), both CRP and PCT elevated showed significantly higher mortality (Odds ratio 1.552 [95% Confidence intervals 1.184-2.035]) than both CRP and PCT not elevated (p = 0.001) and only PCT elevated (p = 0.007). However, both CRP and PCT elevated was also not an independent predictor in multivariate analysis. Initial levels of CRP and PCT alone and their combinations in septic shock patients had a limitation to predict 28-day mortality. Future research is needed to determine new biomarkers for early prognostication in patients with septic shock.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.