Olfactory receptor 43 reduces hepatic lipid accumulation and adiposity in mice
DC Field | Value | Language |
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dc.contributor.author | Wu, Chunyan | - |
dc.contributor.author | Thach, Trung Thanh | - |
dc.contributor.author | Kim, Yeon-Ji | - |
dc.contributor.author | Lee, Sung-Joon | - |
dc.date.accessioned | 2021-09-01T16:51:50Z | - |
dc.date.available | 2021-09-01T16:51:50Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 1388-1981 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/66414 | - |
dc.description.abstract | Olfactory receptors are primarily expressed in nasal olfactory epithelium, but these receptors are also ectopically expressed in diverse tissues. In this study, we investigated the biological functions of Olfr43, a mouse homolog of human OR1A1, in cultured hepatocytes and mice to assess its functionality in lipid metabolism. Olfr43 was expressed in mouse hepatocytes, and Olfr43 activation by a known ligand, (-)-carvone, stimulated cAMP response element-binding protein (CREB) activity. In ligand-receptor binding studies using site-directed mutagenesis, ()-carvone binding required two residues, M257 and Y258, in Olfr43. In the mouse study, oral administration of ()-carvone for 5 weeks in high-fat diet-fed mice improved energy metabolism, including reductions in hepatic steatosis and adiposity, and improved glucose and insulin tolerance. In mouse livers and cultured mouse hepatocytes, Olfr43 activation simulated the CREB-hairy and enhancer of split 1 (HES1)-peroxisome proliferator-activated receptor (PPAR)-gamma signaling axis, leading to a reduction in hepatic triglyceride accumulation in the mouse liver. Thus, long-term administration of (-)-carvone reduces hepatic steatosis. The knockdown of Olfr43 gene expression in cultured hepatocytes negated these effects of (-)-carvone. In conclusion, an ectopic olfactory receptor, hepatic Olfr43, regulates energy metabolism via the CREB-HES1-PPAR gamma signaling axis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | DIET-INDUCED OBESITY | - |
dc.subject | PPAR-GAMMA | - |
dc.subject | ANTIMICROBIAL ACTIVITY | - |
dc.subject | ESSENTIAL OILS | - |
dc.subject | IN-VIVO | - |
dc.subject | CARVONE | - |
dc.subject | EXPRESSION | - |
dc.subject | STEATOSIS | - |
dc.subject | ODORANT | - |
dc.subject | CELLS | - |
dc.title | Olfactory receptor 43 reduces hepatic lipid accumulation and adiposity in mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sung-Joon | - |
dc.identifier.doi | 10.1016/j.bbalip.2019.01.004 | - |
dc.identifier.scopusid | 2-s2.0-85060196720 | - |
dc.identifier.wosid | 000459366300004 | - |
dc.identifier.bibliographicCitation | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v.1864, no.4, pp.489 - 499 | - |
dc.relation.isPartOf | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | - |
dc.citation.title | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | - |
dc.citation.volume | 1864 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 489 | - |
dc.citation.endPage | 499 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | DIET-INDUCED OBESITY | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | ANTIMICROBIAL ACTIVITY | - |
dc.subject.keywordPlus | ESSENTIAL OILS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CARVONE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | STEATOSIS | - |
dc.subject.keywordPlus | ODORANT | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Olfr43 | - |
dc.subject.keywordAuthor | Olfactory receptor | - |
dc.subject.keywordAuthor | (-)-carvone | - |
dc.subject.keywordAuthor | Lipid accumulation | - |
dc.subject.keywordAuthor | cAMP response element-binding protein | - |
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