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Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient
- Authors
- Yeon, Gyu-Bum; Son, Daryeon; Kang, Phil Jun; Oh, Seung-Min; Lim, Hun; Kang, Hoon-Chul; You, Seungkwon; Kim, Dae-Sung
- Issue Date
- 4월-2019
- Publisher
- ELSEVIER
- Citation
- STEM CELL RESEARCH, v.36
- Indexed
- SCIE
SCOPUS
- Journal Title
- STEM CELL RESEARCH
- Volume
- 36
- ISSN
- 1873-5061
- Abstract
- X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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