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Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

Authors
Yeon, Gyu-BumSon, DaryeonKang, Phil JunOh, Seung-MinLim, HunKang, Hoon-ChulYou, SeungkwonKim, Dae-Sung
Issue Date
4월-2019
Publisher
ELSEVIER
Citation
STEM CELL RESEARCH, v.36
Indexed
SCIE
SCOPUS
Journal Title
STEM CELL RESEARCH
Volume
36
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/66463
DOI
10.1016/j.scr.2019.101425
ISSN
1873-5061
Abstract
X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.
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생명과학대학 (생명공학부)
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