Angiotensin inhibition in the developing kidney; tubulointerstitial effect
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Kee Hwan | - |
dc.contributor.author | Yim, Hyung Eun | - |
dc.contributor.author | Bae, Eun Soo | - |
dc.contributor.author | Hong, Young Sook | - |
dc.date.accessioned | 2021-09-01T16:59:54Z | - |
dc.date.available | 2021-09-01T16:59:54Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 0031-3998 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/66485 | - |
dc.description.abstract | BACKGROUND: Renin-angiotensin system (RAS) blockade during nephrogenesis causes a broad range of renal mal-development. Here, we hypothesized that disruption of renal lymphangiogenesis may contribute to tubulointerstitial alterations after RAS blockade during kidney maturation. METHODS: Newborn rat pups were treated with enalapril (30 mg/kg/day) or vehicle for 7 days after birth. Lymphangiogenesis was assessed via immunostaining and/or immunoblots for vascular endothelial growth factor (VEGF)-C, VEGF receptor (VEGFR)-3, Podoplanin, and Ki-67. The intrarenal expression of fibroblast growth factor (FGF)-1, FGF-2, FGF receptor (R)-1, alpha-smooth muscle actin (alpha-SMA), and fibroblast-specific protein (FSP)-1 was also determined. Sirius Red staining was performed to evaluate interstitial collagen deposition. RESULTS: On postnatal day 8, renal lymphangiogenesis was disrupted by neonatal enalapril treatment. The expression of podoplanin and Ki-67 decreased in enalapril-treated kidneys. While the expression of VEGF-C was decreased, the levels of VEGFR-3 receptor increased following enalapril treatment. Enalapril treatment also reduced the renal expression of FGF-1, FGF-2, and FGFR-1. Enalapril-treated kidneys exhibited profibrogenic properties with increased expression of alpha-SMA and FSP-1 and enhanced deposition of interstitial collagen. CONCLUSION: Enalapril treatment during postnatal renal maturation can disrupt renal lymphangiogenesis along with tubulointerstitial changes, which may result in a pro-fibrotic environment in the developing rat kidney. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CONVERTING ENZYME-INHIBITION | - |
dc.subject | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject | LYMPHATIC VASCULATURE | - |
dc.subject | CAPILLARY RAREFACTION | - |
dc.subject | RECEPTORS | - |
dc.subject | FIBROBLASTS | - |
dc.subject | EXPRESSION | - |
dc.subject | FIBROSIS | - |
dc.subject | MITOGEN | - |
dc.title | Angiotensin inhibition in the developing kidney; tubulointerstitial effect | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Kee Hwan | - |
dc.contributor.affiliatedAuthor | Yim, Hyung Eun | - |
dc.identifier.doi | 10.1038/s41390-019-0288-9 | - |
dc.identifier.scopusid | 2-s2.0-85060935067 | - |
dc.identifier.wosid | 000462163600026 | - |
dc.identifier.bibliographicCitation | PEDIATRIC RESEARCH, v.85, no.5, pp.724 - 730 | - |
dc.relation.isPartOf | PEDIATRIC RESEARCH | - |
dc.citation.title | PEDIATRIC RESEARCH | - |
dc.citation.volume | 85 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 724 | - |
dc.citation.endPage | 730 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | CONVERTING ENZYME-INHIBITION | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | LYMPHATIC VASCULATURE | - |
dc.subject.keywordPlus | CAPILLARY RAREFACTION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | MITOGEN | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.