Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Wnt signaling pathway is implicated in the alleviating effect of treadmill exercise on maternal separation-induced depression

Authors
Lee, Jae-MinKim, Tae-WoonPark, Sang-SeoKim, Chang-JuShin, Mal-SoonLee, Sam-JunKim, Sang-HoonBaek, Seung-Soo
Issue Date
4월-2019
Publisher
KOREAN SOC EXERCISE REHABILITATION
Keywords
Wnt signaling; Depression; Maternal separation; Hippocampus; Exercise
Citation
JOURNAL OF EXERCISE REHABILITATION, v.15, no.2, pp.200 - 205
Indexed
SCOPUS
KCI
Journal Title
JOURNAL OF EXERCISE REHABILITATION
Volume
15
Number
2
Start Page
200
End Page
205
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/66517
DOI
10.12965/jer.1938148.074
ISSN
2288-176X
Abstract
Maternal separation in the developmental stage has a negative influence on brain development and causes depression. The extracellular ligand, Wnt, and its receptors play an important role in axis formation and neural development. Exercise inhibits apoptosis, increases cell proliferation, and exerts antidepressive effect In this study, the effect of treadmill exercise on the maternal separation-induced depression was investigated in the aspect of Wnt signaling pathway. The maternal separation started on the postnatal day 14. The rat pups in the exercise groups were forced to run on a treadmill for 30 min once a day from postnatal day 21 to postnatal day 34. The rat pups in the maternal separation and fluoxetine-treated group were intraperitoneally injected with 5-mg/kg fluoxetine once a day from postnatal day 21 to postnatal day 34. Forced swimming test was performed to evaluate the depression level. Western blotting was performed for the expressions of Wnt signaling ligands, Wnt2 and Wnt3a, and Wnt signaling inhibitors, Dkk1, and sFRP3. Maternal separation showed depressive behaviors in the forced swimming test Treadmill exercise alleviated depressive behaviors in the maternal separation rat pups. Expressions of Wnt2 and Wnt3a were decreased by maternal separation. Treadmill exercise alleviated maternal separation-induced reduction of Wnt2 and Wnt3a expressions. Expressions of Dkk1 and sFRP3 in the hippocampus were increased by maternal separation. Treadmill exercise alleviated maternal separation-induced reduction of Dkkl and sFRP3 expressions. Our study demonstrated that treadmill exercise activates Wnt signaling pathway, and then exerted antidepressive effect.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Culture and Sports > Division of Global Sport Studies > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE