Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Retroperitoneal fibrosis in the era of immunoglobulin G4-related disease

Authors
Choi, Yoon KyungYang, Ji HyunAhn, Shin YoungKo, Gang JeeOh, Se WonKim, Myung GyuCho, Won YongJo, Sang Kyung
Issue Date
3월-2019
Publisher
KOREAN SOC NEPHROLOGY
Keywords
Acute kidney injury; Immunoglobulin G4; Retroperitoneal fibrosis; Steroid treatment
Citation
KIDNEY RESEARCH AND CLINICAL PRACTICE, v.38, no.1, pp.42 - 48
Indexed
SCOPUS
KCI
Journal Title
KIDNEY RESEARCH AND CLINICAL PRACTICE
Volume
38
Number
1
Start Page
42
End Page
48
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/67148
DOI
10.23876/j.krcp.18.0052
ISSN
2211-9132
Abstract
Background: Retroperitoneal fibrosis (RPF) is a rare disease characterized by fibroinflammatory tissue in the periaortic or periiliac retroperitoneum, where it frequently encases ureters. There is emerging evidence that a subset of this disease is part of a spectrum of multisystemic autoimmune diseases collectively referred to as "immunoglobulin G4 (IgG4)-related disease". Methods: We retrospectively analyzed 27 idiopathic RPF patients and identified a subset as IgG4-related RPF, which we categorized according to recently published comprehensive diagnostic criteria. We compared clinical and laboratory characteristics and response to treatment between the two groups. Results: Of 27 total patients, 16 (59.3%) were diagnosed as having IgG4-related RPF, and these were predominantly male. They were also significantly older and more likely to have other organ involvement, hydronephrosis, and postrenal acute kidney injury (AKI) compared to those with idiopathic RPF. However, there was no difference in response rate to systemic steroid treatment. Conclusion: IgG4-related RPF accounts for a substantial portion of RPF cases previously identified as "idiopathic RPF" in Korea. Clinical and laboratory characteristics of IgG4-related RPF are similar to those of idiopathic RPF except for a striking male predominance, older age, and higher incidence of postrenal AKI in IgG4-related RPF. More comprehensive, prospective studies are needed to clearly distinguish IgG4-related RPF from idiopathic RPF based on clinical manifestation and to further assess treatment response and long-term prognosis.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Ko, Gang Jee photo

Ko, Gang Jee
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE