A wavelength-tunable and facilely functionable D-A type naphthalene core skeleton: Synthesis, photophysical property, and bio-imaging applications for cells and tissues
- Authors
- Jung, Yuna; Kim, Youngseo; Kim, Na Hee; Lee, Junho; Kim, Kang-Hoon; Jung, Junyang; Huh, Youngbuhm; Jang, Hyeung-Jin; Joo, Jinmyoung; Park, Sungnam; Kim, Dokyoung
- Issue Date
- 3월-2019
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Fluorophore; Bio-imaging; Fluorescence imaging; Two-photon imaging; Membrane probe
- Citation
- DYES AND PIGMENTS, v.162, pp.104 - 111
- Indexed
- SCIE
SCOPUS
- Journal Title
- DYES AND PIGMENTS
- Volume
- 162
- Start Page
- 104
- End Page
- 111
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/67198
- DOI
- 10.1016/j.dyepig.2018.10.016
- ISSN
- 0143-7208
- Abstract
- A new wavelength-tunable and facilely functionable electron donor (D)-acceptor (A) type fluorescent naphthalene core skeleton and its application for cell membrane imaging are reported. The core skeleton shows bright green fluorescence with aldehyde(-CHO) moiety at the electron acceptor site, and its emission wavelength is tuned to blue and red by introducing the moiety of nitrile (CN) and dicyanovinyl (-CH(CN)(2)), respectively, at the acceptor site. In addition, the core skeleton can be readily functionable by introducing a targeting moiety at the extra hydroxyl group. For the first demonstration as a fluorescent probe, a long-chain carbon is introduced and evaluated its bio-imaging ability for the cellular membranes on cells and tissues by using confocal laser scanning microscopy (CLSM) and two-photon microscopy (TPM). The synthesis, photophysical property, and quantum chemical calculations are also identified.
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