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Dual-functional fluorescent molecular rotor for endoplasmic reticulum microviscosity imaging during reticulophagy
- Authors
- He, Ying; Shin, Jinwoo; Gong, Wanjun; Das, Pintu; Qu, Jinghan; Yang, Zhigang; Liu, Wufan; Kang, Chulhun; Qu, Junle; Kim, Jong Seung
- Issue Date
- 28-2월-2019
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.55, no.17, pp.2453 - 2456
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 55
- Number
- 17
- Start Page
- 2453
- End Page
- 2456
- ISSN
- 1359-7345
- Abstract
- The microviscosity change associated with reticulophagy is an important component for studying endoplasmic reticulum (ER) stress disorders. Here, a BODIPY-arsenicate conjugate 1-based fluorescent molecular rotor was designed to covalently bind vicinal dithiol-containing proteins in the ER, exhibiting a bifunction of reticulophagy initiation and microviscosity evaluation. Therefore, we could quantify the local viscosity changes during reticulophagy based on the fluorescence lifetime changes of probe 1.
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