Impact of multi-vessel vasospastic angina on cardiovascular outcome
- Authors
- Han, Seung Hwan; Lee, Kwan Yong; Her, Sung Ho; Ahn, Youngkeun; Park, Keun-Ho; Kim, Dong-Soo; Yang, Tae-Hyun; Choi, Dong-Ju; Suh, Jung-Won; Kwon, Hyuck Moon; Lee, Byoung Kwon; Gwon, Hyeon-Cheol; Rha, Seung-Woon; Jo, Sang-Ho; Ko, Kwang-Pil; Baek, Sang Hong
- Issue Date
- 2월-2019
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Coronary artery disease; Vasospasm; Multi-vessel; Prognosis
- Citation
- ATHEROSCLEROSIS, v.281, pp.107 - 113
- Indexed
- SCIE
SCOPUS
- Journal Title
- ATHEROSCLEROSIS
- Volume
- 281
- Start Page
- 107
- End Page
- 113
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/67751
- DOI
- 10.1016/j.atherosclerosis.2018.12.018
- ISSN
- 0021-9150
- Abstract
- Background and aims: Since clinical characteristics and prognosis of patients with multi-vessel vasospastic angina (VSA) are not clear, we investigated the nature and prognosis of multi-vessel VSA in Koreans. Methods: Among 2960 patients enrolled in the VA-KOREA (Vasospastic Angina in Korea) registry, 104 definite multi-vessel VSA patients, 163 single vessel VSA patients and 737 non-VSA patients were identified using the intracoronary ergonovine provocation test. Results: Multi-vessel VSA and single vessel VSA groups showed similar baseline characteristics and medical treatment on discharge, but different from the non-VSA group. The primary composite endpoint (cardiac death, acute coronary syndrome, and symptomatic new onset arrhythmia) over a 36-month follow-up period was significantly higher in the multi-vessel VSA group than in the single vessel VSA and non-VSA groups (8.7% vs. 1.8% and 1.1%, each log-rank p < 0.05, respectively). The rate of death and acute coronary syndrome of the multi-vessel VSA group was higher than in the single vessel VSA and non-VSA groups (5.8% vs. 1.2% and 0.9%, each log-rank p < 0.05, respectively). In addition, multi-vessel VSA was an independent predictor of the primary composite endpoint at 36 months (HR 8.5, 95% CI [2.6-27.2], p < 0.0001). Conclusions: Patients with multi-vessel VSA had worse clinical outcomes than single vessel VSA and non-VSA groups, suggesting that the existence of multi-vessel VSA itself is highly prognostic.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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