14-3-3 gamma Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors

Abstract

14-3-3 gamma plays diverse roles in different aspects of cellular processes. Especially in the brain where 14-3-3 gamma is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. Williams-Beuren syndrome and Creutzfeldt-Jakob disease). However, behavioral abnormalities related to 14-3-3 gamma deficiency are largely unknown. Here, by using 14-3-3 gamma deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. In addition, in behavioral analyses, we found that 14-3-3 gamma heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. These results suggest that 14-3-3 gamma levels may be involved in the developmental manifestation of related neuropsychiatric diseases. In addition, 14-3-3 gamma heterozygote mice may be a potential model to study the molecular pathophysiology of neuropsychiatric symptoms.