14-3-3 gamma Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors
- Authors
- Kim, Do Eon; Cho, Chang-Hoon; Sim, Kyoung Mi; Kwon, Osung; Hwang, Eun Mi; Kim, Hyung-Wook; Park, Jae-Yong
- Issue Date
- 2월-2019
- Publisher
- KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
- Keywords
- 14-3-3 gamma; Ywhag; Hyperactivity; Anxiety; Acute stress; ADHD
- Citation
- EXPERIMENTAL NEUROBIOLOGY, v.28, no.1, pp.43 - 53
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- EXPERIMENTAL NEUROBIOLOGY
- Volume
- 28
- Number
- 1
- Start Page
- 43
- End Page
- 53
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/67756
- DOI
- 10.5607/en.2019.28.1.43
- ISSN
- 1226-2560
- Abstract
- 14-3-3 gamma plays diverse roles in different aspects of cellular processes. Especially in the brain where 14-3-3 gamma is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. Williams-Beuren syndrome and Creutzfeldt-Jakob disease). However, behavioral abnormalities related to 14-3-3 gamma deficiency are largely unknown. Here, by using 14-3-3 gamma deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. In addition, in behavioral analyses, we found that 14-3-3 gamma heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. These results suggest that 14-3-3 gamma levels may be involved in the developmental manifestation of related neuropsychiatric diseases. In addition, 14-3-3 gamma heterozygote mice may be a potential model to study the molecular pathophysiology of neuropsychiatric symptoms.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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