Laxative effect of probiotic chocolate on loperamide-induced constipation in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Eor, Ju Young | - |
dc.contributor.author | Tan, Pei Lei | - |
dc.contributor.author | Lim, Sei Mi | - |
dc.contributor.author | Choi, Da Hye | - |
dc.contributor.author | Yoon, Seok Min | - |
dc.contributor.author | Yang, Si Young | - |
dc.contributor.author | Kim, Sae Hun | - |
dc.date.accessioned | 2021-09-01T19:51:12Z | - |
dc.date.available | 2021-09-01T19:51:12Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 0963-9969 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/67777 | - |
dc.description.abstract | The fecal morphology, defecation frequency, bowel function, intestinal motility, and fecal bacterial composition were evaluated to investigate the laxative effect of probiotic chocolate containing Streptococcus thermophilus MG510 and Lactobacillus plantarum LRCC5193 (LYC) on loperamide-induced constipated rats. Daily oral administration of LYC in constipated rats for two weeks was shown to significantly increase (n = 14) the defecation frequency, fecal moisture content, and relative abundance of fecal Lactobacillus and Faecalibacterium prausnitzii. Moreover, histological analysis of the distal colon of constipated rats revealed that LYC treatment can also increase the thickness of the colonic mucosa and muscle layers, and crypt of Lieberkiihn. LYC also significantly increased (n = 5) the intestinal motility and modulated (n = 9) mRNA expression levels of colonic 20-1 and Cldn-1 in the constipated rats. Altogether, these results demonstrate that probiotic chocolate has potential as a dietary adjunct for the treatment of constipation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | FAECALIBACTERIUM-PRAUSNITZII A2-165 | - |
dc.subject | LACTOBACILLUS-CASEI 01 | - |
dc.subject | REAL-TIME PCR | - |
dc.subject | QUANTITATIVE PCR | - |
dc.subject | MICROBIOTA | - |
dc.subject | BACTERIA | - |
dc.subject | BARRIER | - |
dc.subject | PERMEABILITY | - |
dc.subject | DYSFUNCTION | - |
dc.subject | ASSOCIATION | - |
dc.title | Laxative effect of probiotic chocolate on loperamide-induced constipation in rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sae Hun | - |
dc.identifier.doi | 10.1016/j.foodres.2018.09.062 | - |
dc.identifier.scopusid | 2-s2.0-85054441153 | - |
dc.identifier.wosid | 000458942900129 | - |
dc.identifier.bibliographicCitation | FOOD RESEARCH INTERNATIONAL, v.116, pp.1173 - 1182 | - |
dc.relation.isPartOf | FOOD RESEARCH INTERNATIONAL | - |
dc.citation.title | FOOD RESEARCH INTERNATIONAL | - |
dc.citation.volume | 116 | - |
dc.citation.startPage | 1173 | - |
dc.citation.endPage | 1182 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | FAECALIBACTERIUM-PRAUSNITZII A2-165 | - |
dc.subject.keywordPlus | LACTOBACILLUS-CASEI 01 | - |
dc.subject.keywordPlus | REAL-TIME PCR | - |
dc.subject.keywordPlus | QUANTITATIVE PCR | - |
dc.subject.keywordPlus | MICROBIOTA | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | BARRIER | - |
dc.subject.keywordPlus | PERMEABILITY | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordAuthor | Probiotic chocolate | - |
dc.subject.keywordAuthor | Streptococcus thermophilus MG510 | - |
dc.subject.keywordAuthor | Lactobacillus plantarum LRCC5193 | - |
dc.subject.keywordAuthor | Constipation | - |
dc.subject.keywordAuthor | Gastrointestinal health | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.