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Linseed polysaccharides based nanoparticles for controlled delivery of docetaxel: Design, in vitro drug release and cellular uptake

Authors
Haseeb, Muhammad TahirUl Khaliq, NisarYuk, Soon HongHussain, Muhammad AjazBashir, Sajid
Issue Date
2월-2019
Publisher
ELSEVIER SCIENCE BV
Keywords
Linseed polysaccharides; Hydrophilic nanoparticles; Docetaxel; Cancer therapy; Pluronic; In vitro drug release
Citation
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v.49, pp.143 - 151
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Volume
49
Start Page
143
End Page
151
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/67804
DOI
10.1016/j.jddst.2018.11.009
ISSN
1773-2247
Abstract
Linseed polysaccharides (LSP) were used to develop a nanoparticle carrier system for the effective delivery of docetaxel (DTX). DTX was loaded in LSP core and further protected by pluronic F-68 shell. Formation, morphology and size distribution of DTX loaded LSP-pluronic nanoparticles (DLP-NPs) were characterized by DLS, FESEM, and PXRD. Spherical shaped DLP-NPs were observed using FESEM image having diameter to be 155 +/- 44 nm depending on the drug loading (DL). Encapsulation efficiency (EE) and DL was found in the range from 98 to 78.33% and 0.98-2.35%, respectively. In vitro drug release studies showed prolong (more than 96 h) and sustain release of DTX from DLP-NPs. The cytotoxicity and cellular uptake study indicated the minimum toxicity of LSP and formulation was found chemotherapeutically effective. Results of the current study demonstrated a potential application of naturally occurring biopolymers in building novel hydrophilic nanoparticle formulation for delivering anticancer therapeutic agents.
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