Usefulness of the Psoriatic Arthritis Screening and Evaluation Questionnaire to Monitor Disease Activity in Management of Patients with Psoriasis: Findings from the EPI-PSODE Study
- Authors
- Choe, Yong Beom; Park, Chul Jong; Yu, Dae Young; Kim, Youngdoe; Ju, Hyun Jeong; Youn, Sang Woong; Lee, Joo-Heung; Kim, Byung Soo; Seo, Seong Jun; Yun, Seok-Kweon; Park, Joonsoo; Kim, Nack In; Youn, Jai Il; Lee, Seok-Jong; Lee, Min-Geol; Kim, Kwang Joong; Ro, Young Suck; Song, Hae Jun; Shin, Bong Seok; Ahn, Sung Ku; Lee, Ji Yeoun; Won, Young Ho; Jang, Min Soo; Kim, Ki Ho; Kim, Myung Hwa; Kim, Tae Yoon; Choi, Jee-Ho
- Issue Date
- 2월-2019
- Publisher
- KOREAN DERMATOLOGICAL ASSOC
- Keywords
- Arthritis; Psoriatic
- Citation
- ANNALS OF DERMATOLOGY, v.31, no.1, pp.29 - 36
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ANNALS OF DERMATOLOGY
- Volume
- 31
- Number
- 1
- Start Page
- 29
- End Page
- 36
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/67820
- DOI
- 10.5021/ad.2019.31.1.29
- ISSN
- 1013-9087
- Abstract
- Background: Psoriasis and psoriatic arthritis (PsA) are included in the group of immune-mediated inflammatory diseases (IMIDs) caused by systemic inflammation; however, indicators for monitoring inflammatory activity in patients with psoriasis, such as the Psoriasis Area and Severity Index (PASI), are limited. Objective: To determine whether the Psoriatic Arthritis Screening and Evaluation (PASE) questionnaire can be used to monitor disease activity in patients with psoriasis. Methods: This was a multicenter, non-interventional, cross-sectional study. Demographic factors and PASI and PASE scores were collected to investigate associations between each. Results: PASE data were available for 1,255 patients, of whom 498 (39.7%) had a score of >= 37. Compared with the group with PASE score < 37, the group with score >= 37 had a higher proportion of women (34.9% vs. 48.8%, p<0.0001), older mean age at diagnosis (36.4 vs. 41.7 years, p<0.0001), more severe disease activity using PASI and body surface area measures (p=0.0021 and p=0.0008, respectively), and higher mean body mass index (23.7 vs. 24.1, p=0.0411). In a multiple linear regression model, PASE score was positively associated with cutaneous disease activity (p<0.0001). Conclusion: After risk-adjustment, PASE was positively associated with PASI, which suggests that PASE can be sensitive to disease activity. Since psoriasis is regarded as one of the IMIDs, PASE may be utilized as a tool not only to screen PsA but also to monitor disease activity.
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