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A rhodamine based fluorescent probe validates substrate and cellular hypoxia specific NADH expression
- Authors
- Podder, Arup; Koo, Seyoung; Lee, Jiyeong; Mun, Sora; Khatun, Sabina; Kang, Hee-Gyoo; Bhuniya, Sankarprasad; Kim, Jong Seung
- Issue Date
- 14-1월-2019
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.55, no.4, pp.537 - 540
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 55
- Number
- 4
- Start Page
- 537
- End Page
- 540
- ISSN
- 1359-7345
- Abstract
- Herein, we report a rhodamine-based redox probe (MQR) to visualize cytosolic NADH in the cellular milieu. Its high sensitivity and selectivity allowed it to track the alteration of the NADH level under metabolic perturbation, suggesting its potential as a useful tool to study the association between the NADH level and metabolic abnormalities with clinical significance.
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